Pain Management
Dolorex®
(butorphanol tartrate)
Indications

DOLOREX® (butorphanol tartrate) is indicated for the relief of pain associated with colic in adult horses and yearlings. Clinical studies in the horse have shown that butorphanol tartrate alleviates abdominal pain associated with torsion, impaction, intussusception, spasmodic and tympanic colic, and postpartum pain.

The Science of Pain Relief

  • Serious relief ‐ For fast-acting relief of moderate to severe pain
  • Rapid onset of action ‐ DOLOREX begins to alleviate pain within 15 minutes of administration
  • Consistent ‐ Pain relief can be maintained for up to four hours
  • Safe ‐ Can be safely re-administered if needed
  • Backed by Merck Animal Health ‐ Included in the trusted pain management portfolio from Merck Animal Health that also includes BANAMINE® (flunixin meglumine) and PHENYLZONE® Paste (phenylbutazone)

Science

Additional Resources

Administration

DOSAGE AND ADMINISTRATION:

The recommended dosage in the horse is 0.1 mg butorphanol per kilogram of body weight (0.05 mg/lb) by intravenous injection. This is equivalent to 5 mL DOLOREX for each 1,000 lb body weight. The dose may be repeated within 3 to 4 hours but treatment should not exceed 48 hours. Preclinical model studies and clinical field trials in horses demonstrate that the analgesic effects of butorphanol are seen within 15 minutes following injection and persist for about 4 hours.

For use in horses only. Not for use in horses intended for human consumption. DOLOREX, a potent analgesic, should be used with caution with other sedative or analgesic drugs as these are likely to produce additive effects. There are no well controlled studies using butorphanol in breeding horses, weanlings and foals. Therefore the drug should not be used in these groups.

WARNING FOR USE IN HORSES ONLY. NOT FOR USE IN HORSES INTENDED FOR FOOD.

CAUTION DOLOREX, a potent analgesic, should be used with caution with other sedative or analgesic drugs as these are likely to produce additive effects. There are no well controlled studies using butorphanol in breeding horses, weanlings, and foals. Therefore the drug should not be used in these groups.

ADVERSE REACTIONS In clinical trials in horses, the most commonly observed side effect was slight ataxia which lasted 3 to 10 minutes. Marked ataxia was reported in 1.5% of the 327 horses treated. Mild sedation was reported in 9% of the horses.